L-arginine and mitomycin C-induced nitric oxide release and apoptosis in human lymphocytes
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nitric oxide (NO) is a free radical that is produced by a number of mammalian cell types from L-arginine and a critical mediator that acts in many tissues to regulate a diverse range of physiological processes. The major metabolic end product for NO is nitrate (NO2) and nitrite (NO2), which are stable metabolites within tissue, plasma, and urine. Measurements of nitrate and nitrite values reveal alterations in NO production. Endogenously generated or exogenously applied NO causes DNA cleavage by endonuclease activation. We investigated the effect Of L-arginine and mitomycin C (MMC) on cultured lymphocytes of healthy individuals. We observed chromosome breaks, apoptotic cells and increased NO levels after L-arginine and MMC addition. In conclusion, our results confirmed that NO may be the cause of apoptotic cell death in L-arginine added lymphocyte culture. (C) 2003 Elsevier Science Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
nitric oxide, L-arginine, mitomycin C, apoptosis
Kaynak
CELL BIOLOGY INTERNATIONAL
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
27
Sayı
4
