L-arginine and mitomycin C-induced nitric oxide release and apoptosis in human lymphocytes

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dc.authorid0000-0001-9696-0433en_US
dc.contributor.authorErden, CD
dc.contributor.authorEkmekci, A
dc.contributor.authorSahin, FI
dc.contributor.authorErgun, MA
dc.contributor.authorOzturk, G
dc.contributor.authorErbas, D
dc.date.accessioned2024-07-12T21:45:32Z
dc.date.available2024-07-12T21:45:32Z
dc.date.issued2003en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractNitric oxide (NO) is a free radical that is produced by a number of mammalian cell types from L-arginine and a critical mediator that acts in many tissues to regulate a diverse range of physiological processes. The major metabolic end product for NO is nitrate (NO2) and nitrite (NO2), which are stable metabolites within tissue, plasma, and urine. Measurements of nitrate and nitrite values reveal alterations in NO production. Endogenously generated or exogenously applied NO causes DNA cleavage by endonuclease activation. We investigated the effect Of L-arginine and mitomycin C (MMC) on cultured lymphocytes of healthy individuals. We observed chromosome breaks, apoptotic cells and increased NO levels after L-arginine and MMC addition. In conclusion, our results confirmed that NO may be the cause of apoptotic cell death in L-arginine added lymphocyte culture. (C) 2003 Elsevier Science Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S1065-6995(02)00350-5
dc.identifier.endpage340en_US
dc.identifier.issn1065-6995
dc.identifier.issue4en_US
dc.identifier.pmid12788049en_US
dc.identifier.scopus2-s2.0-0038440762en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S1065-6995(02)00350-5
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7840
dc.identifier.volume27en_US
dc.identifier.wosWOS:000182510000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherACADEMIC PRESS LTD ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofCELL BIOLOGY INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00487
dc.subjectnitric oxideen_US
dc.subjectL-arginineen_US
dc.subjectmitomycin Cen_US
dc.subjectapoptosisen_US
dc.titleL-arginine and mitomycin C-induced nitric oxide release and apoptosis in human lymphocytesen_US
dc.typeArticle
dspace.entity.typePublication

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