The effects of rifampicin and fluoroquinolones on tubercle bacilli within human macrophages

Küçük Resim Yok

Tarih

2004

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Araştırma projeleri

Organizasyon Birimleri

Dergi sayısı

Özet

The objective of this study was to determine the activities of rifampicin, ciprofloxacin and sparfloxacin against M. tuberculosis H37Rv in human macrophages. The minimal inhibitory concentrations (MIC) were determined by agar macrodilution and broth microdilution methods and were 0.5, 1 and 0.125mg/l, respectively. Concentrations of rifampicin at 0.5 and 2.5µg (P<0.001), ciprofloxacin at 4 and 8µg (P<0.001) and sparfloxacin at 0.125µg (P<0.05), 0.625µg (P<0.001) and 1.25µg (P<0.001) were found to be effective against intracellular bacteria. Ciprofloxacin and especially sparfloxacin were effective in macrophages and may be useful in the treatment of tuberculosis particularly infections caused by multiply drug resistant strains. © 2003 Published by Elsevier B.V. and the International Society of Chemotherapy.

Açıklama

Anahtar Kelimeler

Fluoroquinolones, Human macrophage, M. tuberculosis, Rifampicin

Kaynak

International Journal of Antimicrobial Agents

WoS Q Değeri

Q2

Scopus Q Değeri

Q1

Cilt

23

Sayı

1

Künye