The effects of rifampicin and fluoroquinolones on tubercle bacilli within human macrophages
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The objective of this study was to determine the activities of rifampicin, ciprofloxacin and sparfloxacin against M. tuberculosis H37Rv in human macrophages. The minimal inhibitory concentrations (MIC) were determined by agar macrodilution and broth microdilution methods and were 0.5, 1 and 0.125mg/l, respectively. Concentrations of rifampicin at 0.5 and 2.5µg (P<0.001), ciprofloxacin at 4 and 8µg (P<0.001) and sparfloxacin at 0.125µg (P<0.05), 0.625µg (P<0.001) and 1.25µg (P<0.001) were found to be effective against intracellular bacteria. Ciprofloxacin and especially sparfloxacin were effective in macrophages and may be useful in the treatment of tuberculosis particularly infections caused by multiply drug resistant strains. © 2003 Published by Elsevier B.V. and the International Society of Chemotherapy.
Açıklama
Anahtar Kelimeler
Fluoroquinolones, Human macrophage, M. tuberculosis, Rifampicin
Kaynak
International Journal of Antimicrobial Agents
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
23
Sayı
1
