The effects of rifampicin and fluoroquinolones on tubercle bacilli within human macrophages

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dc.contributor.authorDuman N.
dc.contributor.authorÇevikbaş A.
dc.contributor.authorJohansson C.
dc.date.accessioned2024-07-12T21:49:57Z
dc.date.available2024-07-12T21:49:57Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe objective of this study was to determine the activities of rifampicin, ciprofloxacin and sparfloxacin against M. tuberculosis H37Rv in human macrophages. The minimal inhibitory concentrations (MIC) were determined by agar macrodilution and broth microdilution methods and were 0.5, 1 and 0.125mg/l, respectively. Concentrations of rifampicin at 0.5 and 2.5µg (P<0.001), ciprofloxacin at 4 and 8µg (P<0.001) and sparfloxacin at 0.125µg (P<0.05), 0.625µg (P<0.001) and 1.25µg (P<0.001) were found to be effective against intracellular bacteria. Ciprofloxacin and especially sparfloxacin were effective in macrophages and may be useful in the treatment of tuberculosis particularly infections caused by multiply drug resistant strains. © 2003 Published by Elsevier B.V. and the International Society of Chemotherapy.en_US
dc.identifier.doi10.1016/j.ijantimicag.2003.05.017
dc.identifier.endpage87en_US
dc.identifier.issn0924-8579
dc.identifier.issue1en_US
dc.identifier.pmid14732319en_US
dc.identifier.scopus2-s2.0-0347090626en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijantimicag.2003.05.017
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8112
dc.identifier.volume23en_US
dc.identifier.wosWOS:000189096900014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01618
dc.subjectFluoroquinolonesen_US
dc.subjectHuman macrophageen_US
dc.subjectM. tuberculosisen_US
dc.subjectRifampicinen_US
dc.titleThe effects of rifampicin and fluoroquinolones on tubercle bacilli within human macrophagesen_US
dc.typeArticle
dspace.entity.typePublication

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