What does the broken brain say to the neuroscientist? Oscillations and connectivity in schizophrenia, Alzheimer's disease, and bipolar disorder

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dc.contributor.authorBasar, Erol
dc.contributor.authorSchmiedt-Fehr, Christina
dc.contributor.authorMathes, Birgit
dc.contributor.authorFemir, Banu
dc.contributor.authorEmek-Savas, Derya Durusu
dc.contributor.authorTülay, Elif
dc.contributor.authorTan, Devran
dc.contributor.authorDüzgün, Aysel
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorÖzerdem, Ayşegül
dc.contributor.authorYener, Görsev
dc.contributor.authorBaşar-Eroğlu, Canan
dc.date.accessioned2024-07-12T21:14:15Z
dc.date.available2024-07-12T21:14:15Z
dc.date.issued2016en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe application of the concept and methods of brain oscillations has been an important research area in neurosciences. In the last decades, besides the application in cognitive processes, the study of changes in brain oscillations in diseases has also become an important focal point of research. In the present paper, some remarkable examples in three different diseases are taken into consideration: 1) schizophrenia (SZ), 2) Alzheimer's disease (AD), 3) bipolar disorders (BD). In the current literature, decreased oscillations in cortical recordings are observed in most of the pathologies. For example, decrease of gamma activity in SZ, decrease of delta activity in almost all diseases, as well as frequency shifts in alpha and the lower frequencies were recorded. However, there are also paradoxical cases in which an increase of oscillatory activities is observed. In BD, whereas alpha activity is greatly decreased, a huge increase of beta activity is observed. Or, in SZ, a paradoxical increase of gamma activity can be observed during cognitive loading. We also observed paradoxical changes in the analysis of connectivity. In AD, we find that alpha, delta, and theta coherences between distant parts of the cortex are greatly decreased, whereas in the gamma band, event-related coherences attain very high values. The comparison of the results and paradoxical changes in diseases may lead to important conclusions related to the web of oscillations and neurotransmitters. In turn, we could gain new insights to approach "brain function", in general. (C) 2016 The Authors. Published by Elsevier B.V.en_US
dc.identifier.doi10.1016/j.ijpsycho.2015.02.004
dc.identifier.endpage148en_US
dc.identifier.issn0167-8760
dc.identifier.issn1872-7697
dc.identifier.pmid25660302en_US
dc.identifier.scopus2-s2.0-84923544313en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijpsycho.2015.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4608
dc.identifier.volume103en_US
dc.identifier.wosWOS:000379093200015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science BVen_US
dc.relation.ispartofInternational Journal of Psychophysiologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY09269
dc.subjectOscillationsen_US
dc.subjectConnectivityen_US
dc.subjectSchizophreniaen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectBipolar disorderen_US
dc.titleWhat does the broken brain say to the neuroscientist? Oscillations and connectivity in schizophrenia, Alzheimer's disease, and bipolar disorderen_US
dc.typeReview
dspace.entity.typePublication

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