Attenuated lactate response to ischemic exercise in migraine
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
INT SCIENTIFIC LITERATURE, INC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Although the pathogenesis of migraine still remains unclear, certain metabolic studies done on patients with migraine indicate possible deficits in mitochondrial activity. Previously, the forearm ischemic exercise test (FIT) has been used as a screening tool to evaluate mitochondrial dysfunction in metabolic myopathies. Material/Methods: We studied the response of migraine patients to exercise using the modified FIT and compared this to the responses in a healthy group. After baseline venous blood samples were drawn, a sphygmomanometer cuff placed around the upper arm was inflated to 30 mmHg above systolic blood pressure and the subject performed a maximal isometric contraction of the forearm flexors using a hand-grip dynamometer with a 9-contraction: 1-relaxation duty cycle for a total time of 60 seconds. Results: In migraine patients, attenuated lactate response after the FIT in the 1(st), 3(rd) and 5(th) minutes were significantly different when compared to the control group. Conclusions: Our results show that there may be defects in the anaerobic or proximal glycolytic pathways in migraine patients, evident in stressful situations. We also conclude that the FIT may be useful for research on migraine pathophysiology.
Açıklama
Anahtar Kelimeler
headache, pathophysiology, lactate response, mitochondrial, anaerobic metabolism
Kaynak
MEDICAL SCIENCE MONITOR
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
16
Sayı
8
