Attenuated lactate response to ischemic exercise in migraine

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dc.authorid0000-0003-2016-9965en_US
dc.authorid0000-0003-2016-9965en_US
dc.authorid0000-0003-3868-3137en_US
dc.authorid0000-0002-2887-9235en_US
dc.contributor.authorSahin, Sevki
dc.contributor.authorCinar, Nilgun
dc.contributor.authorAksungar, Fehime Benli
dc.contributor.authorAyalp, Sunay
dc.contributor.authorKarsidag, Sibel
dc.date.accessioned2024-07-12T21:51:57Z
dc.date.available2024-07-12T21:51:57Z
dc.date.issued2010en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Although the pathogenesis of migraine still remains unclear, certain metabolic studies done on patients with migraine indicate possible deficits in mitochondrial activity. Previously, the forearm ischemic exercise test (FIT) has been used as a screening tool to evaluate mitochondrial dysfunction in metabolic myopathies. Material/Methods: We studied the response of migraine patients to exercise using the modified FIT and compared this to the responses in a healthy group. After baseline venous blood samples were drawn, a sphygmomanometer cuff placed around the upper arm was inflated to 30 mmHg above systolic blood pressure and the subject performed a maximal isometric contraction of the forearm flexors using a hand-grip dynamometer with a 9-contraction: 1-relaxation duty cycle for a total time of 60 seconds. Results: In migraine patients, attenuated lactate response after the FIT in the 1(st), 3(rd) and 5(th) minutes were significantly different when compared to the control group. Conclusions: Our results show that there may be defects in the anaerobic or proximal glycolytic pathways in migraine patients, evident in stressful situations. We also conclude that the FIT may be useful for research on migraine pathophysiology.en_US
dc.identifier.endpageCR382en_US
dc.identifier.issn1234-1010
dc.identifier.issue8en_US
dc.identifier.pmid20671614en_US
dc.identifier.scopus2-s2.0-77955331813en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageCR378en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8335
dc.identifier.volume16en_US
dc.identifier.wosWOS:000280762400015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherINT SCIENTIFIC LITERATURE, INCen_US
dc.relation.ispartofMEDICAL SCIENCE MONITORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02886
dc.subjectheadacheen_US
dc.subjectpathophysiologyen_US
dc.subjectlactate responseen_US
dc.subjectmitochondrialen_US
dc.subjectanaerobic metabolismen_US
dc.titleAttenuated lactate response to ischemic exercise in migraineen_US
dc.typeArticle
dspace.entity.typePublication

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