Evaluation of the Relationship Between T Regulatory Cells and Vitamin D Levels in Chronic Spontaneous Urticaria

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dc.authorid0000-0002-6041-3806en_US
dc.contributor.authorBulur, Isil
dc.contributor.authorErdogan, Hilal Kaya
dc.contributor.authorYigitaslan, Semra
dc.contributor.authorAkay, Iga Meltem
dc.contributor.authorSaracoglu, Zeynep Nurhan
dc.date.accessioned2024-07-12T21:53:38Z
dc.date.available2024-07-12T21:53:38Z
dc.date.issued2018en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: T regulatory (Treg) cells play a role in autoimmunity and vitamin D is one of the factors involved in regulation of Treg cells. In this study, it is aimed to evaluate the relationship between Treg cells and disease-related parameters and serum vitamin D levels in chronic spontaneous urticaria (CSU) patients. Methods: The percentage of Treg cells were evaluated by flow cytometric analysis and serum 25 hydroxy vitamin D (25(OH)Vit D) levels were determined by commercial available ELISA kit. Results: Thirty eight CSU patients and 30 healthy controls were included in the study. The percentage of CD4(+)CD25(+) and CD4(+)FOXP3(+) T cells in the patient group were found lower than in the control group (p=0.018, p=0.000). No difference was detected between groups in terms of the percentage of CD4(+)CD25(+)FOXP3(+) T cells and the 25(OH) Vit D levels (p=0.192, p=0.218). There was no significant relationship between disease duration, weekly urticaria activity score, autologous serum skin test (ASST), serum 25(OH) Vit D levels and the percentage of Treg cells in CSU patients. Conclusion: The percentage of CD4(+)CD25(+) and CD4(+)FOXP3(+) T cells in CSU patients were observed to be lower than control group independent from the serum 25(OH)Vit D levels, ASST positivity, disease duration and severity. This result suggests that Treg cells are one of the factors involved in the pathogenesis of CSU.en_US
dc.identifier.doi10.4274/tdd.3720
dc.identifier.endpage176en_US
dc.identifier.issn1307-7635
dc.identifier.issn1308-5255
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85058540449en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage172en_US
dc.identifier.trdizinid305628en_US
dc.identifier.urihttps://dx.doi.org/10.4274/tdd.3720
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8526
dc.identifier.volume12en_US
dc.identifier.wosWOS:000451869700003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherGALENOS YAYINCILIKen_US
dc.relation.ispartofTURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03637
dc.subjectChronic spontaneous urticariaen_US
dc.subjectT regulatory cellsen_US
dc.subjectvitamin Den_US
dc.subjecturticaria activity scoreen_US
dc.subjectautologous serum skin testen_US
dc.subjectautoimmunityen_US
dc.titleEvaluation of the Relationship Between T Regulatory Cells and Vitamin D Levels in Chronic Spontaneous Urticariaen_US
dc.typeArticle
dspace.entity.typePublication

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