Evaluation of the Relationship Between T Regulatory Cells and Vitamin D Levels in Chronic Spontaneous Urticaria
dc.authorid | 0000-0002-6041-3806 | en_US |
dc.contributor.author | Bulur, Isil | |
dc.contributor.author | Erdogan, Hilal Kaya | |
dc.contributor.author | Yigitaslan, Semra | |
dc.contributor.author | Akay, Iga Meltem | |
dc.contributor.author | Saracoglu, Zeynep Nurhan | |
dc.date.accessioned | 2024-07-12T21:53:38Z | |
dc.date.available | 2024-07-12T21:53:38Z | |
dc.date.issued | 2018 | en_US |
dc.department | Maltepe Üniversitesi | en_US |
dc.description.abstract | Objective: T regulatory (Treg) cells play a role in autoimmunity and vitamin D is one of the factors involved in regulation of Treg cells. In this study, it is aimed to evaluate the relationship between Treg cells and disease-related parameters and serum vitamin D levels in chronic spontaneous urticaria (CSU) patients. Methods: The percentage of Treg cells were evaluated by flow cytometric analysis and serum 25 hydroxy vitamin D (25(OH)Vit D) levels were determined by commercial available ELISA kit. Results: Thirty eight CSU patients and 30 healthy controls were included in the study. The percentage of CD4(+)CD25(+) and CD4(+)FOXP3(+) T cells in the patient group were found lower than in the control group (p=0.018, p=0.000). No difference was detected between groups in terms of the percentage of CD4(+)CD25(+)FOXP3(+) T cells and the 25(OH) Vit D levels (p=0.192, p=0.218). There was no significant relationship between disease duration, weekly urticaria activity score, autologous serum skin test (ASST), serum 25(OH) Vit D levels and the percentage of Treg cells in CSU patients. Conclusion: The percentage of CD4(+)CD25(+) and CD4(+)FOXP3(+) T cells in CSU patients were observed to be lower than control group independent from the serum 25(OH)Vit D levels, ASST positivity, disease duration and severity. This result suggests that Treg cells are one of the factors involved in the pathogenesis of CSU. | en_US |
dc.identifier.doi | 10.4274/tdd.3720 | |
dc.identifier.endpage | 176 | en_US |
dc.identifier.issn | 1307-7635 | |
dc.identifier.issn | 1308-5255 | |
dc.identifier.issue | 4 | en_US |
dc.identifier.scopus | 2-s2.0-85058540449 | en_US |
dc.identifier.scopusquality | Q4 | en_US |
dc.identifier.startpage | 172 | en_US |
dc.identifier.trdizinid | 305628 | en_US |
dc.identifier.uri | https://dx.doi.org/10.4274/tdd.3720 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12415/8526 | |
dc.identifier.volume | 12 | en_US |
dc.identifier.wos | WOS:000451869700003 | en_US |
dc.identifier.wosquality | N/A | en_US |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | TR-Dizin | |
dc.language.iso | en | en_US |
dc.publisher | GALENOS YAYINCILIK | en_US |
dc.relation.ispartof | TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.snmz | KY03637 | |
dc.subject | Chronic spontaneous urticaria | en_US |
dc.subject | T regulatory cells | en_US |
dc.subject | vitamin D | en_US |
dc.subject | urticaria activity score | en_US |
dc.subject | autologous serum skin test | en_US |
dc.subject | autoimmunity | en_US |
dc.title | Evaluation of the Relationship Between T Regulatory Cells and Vitamin D Levels in Chronic Spontaneous Urticaria | en_US |
dc.type | Article | |
dspace.entity.type | Publication |