Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas

Basit Öğe Kaydı
dc.authoridNARLİ ISSİN, gizem/0000-0002-3688-2768en_US
dc.authoridYILMAZ, ISMAIL/0000-0003-2163-1795en_US
dc.contributor.authorIssin, Gizem
dc.contributor.authorKucukodaci, Zafer
dc.contributor.authorYılmaz, Ismail
dc.contributor.authorErkul, Evren
dc.contributor.authorTural, Ersin
dc.contributor.authorDemirel, Dilaver
dc.contributor.authorGüngör, Atila
dc.date.accessioned2024-07-12T21:37:43Z
dc.date.available2024-07-12T21:37:43Z
dc.date.issued2021en_US
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: Although squamous cell carcinomas (SCCs) originating from different anatomic localizations display a similar histological appearance under light microscopy, they may differ in terms of epigenetic and genetic features. The aim of this study was to analyze mir-126, mir-182, and mir-486-5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles. Material and Method: The expression levels of mir-126, mir-182, and mir-486-5p were analyzed in lung, oral cavity, laryngeal, and hypopharyngeal SCCs in 40 patients, using quantitative real-time polymerase chain reaction. Results: The findings showed that lung, oral cavity, laryngeal, and hypopharyngeal SCCs have distinct mir-126 and mir-486-5p expression profiles. It was also observed that mir-126 and mir-486-5p expression levels were highly specific to the tumor localization. Conclusion: These findings highlighted that SCCs originating from different anatomic localizations have different miRNA expression profiles. miRNA expression analysis can be used to predict the primary localizations of those SCCs.en_US
dc.description.sponsorshipGülhane Military Medical Academy, Haydarpasa Training Hospital Epidemiology Committeeen_US
dc.description.sponsorshipThis study was supported by the Gülhane Military Medical Academy, Haydarpasa Training Hospital Epidemiology Committee.en_US
dc.identifier.doi10.5146/tjpath.2021.01528
dc.identifier.endpage114en_US
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue2en_US
dc.identifier.pmid33973644en_US
dc.identifier.scopus2-s2.0-85105724171en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage106en_US
dc.identifier.trdizinid523077en_US
dc.identifier.urihttps://doi.org/10.5146/tjpath.2021.01528
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/523077
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6907
dc.identifier.volume37en_US
dc.identifier.wosWOS:000648892700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherFederation Turkish Pathology Socen_US
dc.relation.ispartofTurkish Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04249
dc.subjectHead And Necken_US
dc.subjectLungen_US
dc.subjectSquamous Cell Carcinomaen_US
dc.subjectMir-126en_US
dc.subjectMir-182en_US
dc.subjectMir-486-5pen_US
dc.titleEvaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomasen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu