Disrupted latent decision processes in medication-free pediatric OCD patients

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dc.authorid0000-0003-3390-9352en_US
dc.authorid0000-0003-3379-3986en_US
dc.authorid0000-0002-7085-0903en_US
dc.contributor.authorErhan, Ceyla
dc.contributor.authorBulut, Gresa Carkaxhiu
dc.contributor.authorGokce, Sebla
dc.contributor.authorOzbas, Duru
dc.contributor.authorTurkakin, Esin
dc.contributor.authorDursun, Onur Burak
dc.contributor.authorYazgan, Yanki
dc.contributor.authorBalci, Fuat
dc.date.accessioned2024-07-12T21:50:08Z
dc.date.available2024-07-12T21:50:08Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Decision-making in Obsessive Compulsive Disorder has typically been investigated in the adult population. Computational approaches have recently started to get integrated into these studies. However, decision-making research in pediatric OCD populations is scarce. Methods: We investigated latent decision processes in 21 medication-free pediatric OCD patients and 23 healthy control participants. We hypothesized that OCD patients would be more cautious and less efficient in evidence accumulation than controls in a two alternative forced choice (2AFC) task. Results: Pediatric OCD patients were less efficient than controls in accumulating perceptual evidence and showed a tendency to be more cautious. In comparison to post-correct decisions, OCD patients increased decision thresholds after erroneous decisions, whereas healthy controls decreased decision thresholds. These changes were coupled with weaker evidence accumulation after errors in both groups. Limitations: The small sample size limited the power of the study. Conclusions: Our results demonstrate poorer decision-making performance in pediatric OCD patients at the level of latent processes, specifically in terms of evidence accumulation. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.description.sponsorshipWe would like to thank Hakan Karsilar for his help on the DMDT code; Elif Akin for her help in recruiting participants; Aysu Hazar for her help with data collection. This work was supported by the Turkish Academy of Sciences under grant GEBIP 2015 to Fuat Balci. The sponsor had no role, in study design; in the collection, analysis or interpretation of data; in the writing of the report; or in the decision to submit the article for publication.en_US
dc.identifier.doi10.1016/j.jad.2016.09.011
dc.identifier.endpage37en_US
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.pmid27690351en_US
dc.identifier.scopus2-s2.0-84988867596en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jad.2016.09.011
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8133
dc.identifier.volume207en_US
dc.identifier.wosWOS:000389088600005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF AFFECTIVE DISORDERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01786
dc.subjectDecision makingen_US
dc.subjectHierarchical Drift Diffusion Modelen_US
dc.subjectObsessive Compulsive Disorderen_US
dc.subjectChildrenen_US
dc.titleDisrupted latent decision processes in medication-free pediatric OCD patientsen_US
dc.typeArticle
dspace.entity.typePublication

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