Correlation between leptin and pro-inflammatory cytokines in cortical contusion injury model

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dc.authorid0000-0003-3868-3137en_US
dc.contributor.authorKaraoglan, Alper
dc.contributor.authorAkdemir, Osman
dc.contributor.authorCinar, Nilgun
dc.contributor.authorCal, Mehmet Alpay
dc.contributor.authorKelten, Bilal
dc.contributor.authorUzun, Hafize
dc.contributor.authorColak, Ahmet
dc.date.accessioned2024-07-12T21:56:51Z
dc.date.available2024-07-12T21:56:51Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBACKGROUND The present study aimed to investigate time-dependent changes in leptin concentrations in brain tissue following experimental traumatic brain injury and to examine the relationship with cytokines. METHODS After circular craniectomy, 33 male Wistar-albino rats were positioned on a stereotaxic frame and subjected to cortical contusion injury and then divided into 3 groups based on the depth of deformation as: 0 mm (sham controls, n=3), 1.5 mm (moderate injury, n=15) and 2.7 mm (severe injury, n=15). Animals were sacrificed on the 1st, 3rd and 5th days post-injury. RESULTS One day after moderate injury, interleukin-1 beta (IL-1 beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), and leptin levels were found to be markedly increased in the brain tissue. On the 3rd and 5th days, the levels returned to the sham-control levels. Following severe injury, IL-1 beta, IL-6 and TNF-alpha levels increased in correlation after the 1st day and reached the sham-control levels on the same days. However, leptin tissue levels decreased on the 1st and 3rd days and normalized to the sham-control levels on the 5th day. CONCLUSION Our results showed that the release of leptin is decreased in the early stage of severe injury. Thus, leptin replacement may play an important role in therapy in cases with severe traumatic brain injury.en_US
dc.identifier.doi10.5505/tjtes.2011.69077
dc.identifier.endpage302en_US
dc.identifier.issn1306-696X
dc.identifier.issue4en_US
dc.identifier.pmid21935825en_US
dc.identifier.scopus2-s2.0-80051754457en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage298en_US
dc.identifier.trdizinid135417en_US
dc.identifier.urihttps://dx.doi.org/10.5505/tjtes.2011.69077
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8618
dc.identifier.volume17en_US
dc.identifier.wosWOS:000294350400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTURKISH ASSOC TRAUMA EMERGENCY SURGERYen_US
dc.relation.ispartofULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03924
dc.subjectInterleukin-1 betaen_US
dc.subjectinterleukin-6en_US
dc.subjectleptinen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.subjecttraumatic brain injuryen_US
dc.titleCorrelation between leptin and pro-inflammatory cytokines in cortical contusion injury modelen_US
dc.typeArticle
dspace.entity.typePublication

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