The Effect of Vitamin D Prophylaxis on 25-OH Vitamin D Levels in Children

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dc.contributor.authorGül, İhsan
dc.contributor.authorGur, Emel
dc.contributor.authorErcan, Tuğba Erener
dc.contributor.authorCan, Gunay
dc.date.accessioned2024-07-12T21:40:08Z
dc.date.available2024-07-12T21:40:08Z
dc.date.issued2021en_US
dc.department[Belirlenecek]en_US
dc.description.abstractBackground: Vitamin D deficiency is a major public health problem. The aim of our study was to determine serum 25-hydroxyvitamin D levels among healthy children aged 3-36 months in a setting where vitamin D prophylaxis is a national policy for infants during the first year of life and among pregnant women. Methods: A total of 190 healthy children with a mean age of 15.9 +/- 10.4 months were prospectively enrolled. Results: The mean 25-hydroxyvitamin D level of children was 38.1 +/- 16.2 ng/mL. 25-Hydroxyvitamin D level was >= 20 ng/mL in 87.4% of children while it was between 12 and 19 ng/mL in 10.5% and <12 ng/mL in 2.1% of the children. Children who were on vitamin D prophylaxis were found to have significantly higher 25-hydroxyvitamin D levels than those who were not on prophylaxis (41.6 +/- 17.6 vs 33.6 +/- 13.1 ng/mL; P = .001). None of the children >1 year of age who were on prophylaxis had 25-hydroxyvitamin D levels <20 ng/mL. No significant difference in 25-hydroxyvitamin D levels was found between children who were receiving different vitamin D doses (400 IU vs >400 IU). Analysis of covariance revealed that vitamin D prophylaxis and vitamin D supplementation of the mother during lactation had significant effects on 25-hydroxyvitamin D levels (P = .034 and P = .009, respectively). Conclusion: Although vitamin D prophylaxis at a dose of 400 IU seems to be sufficient to prevent vitamin D deficiency, we suggest that continuing vitamin D supplementation beyond 1 year of age with supplementation of pregnant and especially lactating mothers could have an impact on a replete vitamin D status among infants.en_US
dc.description.sponsorshipScientific Project Department of Istanbul University [32982]en_US
dc.description.sponsorshipThis study is supported by the Scientific Project Department of Istanbul University with project no. 32982.en_US
dc.identifier.doi10.5152/TurkArchPediatr.2021.21166
dc.identifier.endpage623en_US
dc.identifier.issn2757-6256
dc.identifier.issue6en_US
dc.identifier.pmid35110062en_US
dc.identifier.scopus2-s2.0-85121633531en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage618en_US
dc.identifier.trdizinid507585en_US
dc.identifier.urihttps://doi.org/10.5152/TurkArchPediatr.2021.21166
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/507585
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7156
dc.identifier.volume56en_US
dc.identifier.wosWOS:000721240100013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Archives of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY05023
dc.subjectChildrenen_US
dc.subjectVitamin D Deficiencyen_US
dc.subjectVitamin D Statusen_US
dc.subject25-Oh Vitamin Den_US
dc.titleThe Effect of Vitamin D Prophylaxis on 25-OH Vitamin D Levels in Childrenen_US
dc.typeArticle
dspace.entity.typePublication

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