LC–MS/MS analysis, antioxidant and anticancer efects of phenolic?rich extracts from Algerian propolis: a comparative study

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dc.authorid0000-0002-7526-8496en_US
dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorBoulechfar, Safia
dc.contributor.authorTepe, Hafize Dilek
dc.contributor.authorZellagui, Amar
dc.contributor.authorBensouici, Chawki
dc.contributor.authorDoyuk, Fatma
dc.contributor.authorKhattabi, Latifa
dc.contributor.authorLahouel, Mesbah
dc.date.accessioned2024-07-12T21:04:40Z
dc.date.available2024-07-12T21:04:40Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe present study was aimed to compare the phenolic composition and the functional properties (antioxidant and anticancer) of phenolic-rich extracts of two different propolis collected from Collo (PREPC) and Oum El Bouaghi (PREPO) regions. The phenolic composition was determined using LC/MS–MS. The antioxidant activity of the extracts was evaluated using alkaline DMSO and ?-carotene-linoleic acid tests. Anticancer effect on HepG2 human hepatocellular carcinoma cells was determined using CCK-8 assay. Twenty-two phenolic compounds in PREPC and twenty-three in PREPO were detected and quantified by LC–MS/MS. Ferulic and caffeic acids were found to be the predominant compounds. Both extracts were able to inhibit lipid peroxidation and demonstrated their ability to scavenge superoxide radicals more effectively than the standards. The highest lipid peroxidation inhibition (IC50?=?17.58?±?1.98 ?g/mL) and superoxide radical scavenging effects (IC50?=?6.19?±?0.24 ?g/mL) were exhibited by PREPO. However, PREPC showed stronger cytotoxic activity against HepG2 (IC50?=?12.22?±?0.05 µg/mL) than PREPO (IC50?=?18.68?±?0.33 µg/mL). These results demonstrate the potential of extracts from Algerian propolis to be used in functional formulations.en_US
dc.identifier.citationBoulechfar, S., Akbulut, Z., Tepe, H.D. et al. (2022) LC–MS/MS analysis, antioxidant and anticancer efects of phenolic?rich extracts from Algerian propolis: a comparative study. Journal of Food Measurement and Characterization, Springer. s. 1-12.en_US
dc.identifier.doi10.1007/s11694-022-01652-3
dc.identifier.endpage12en_US
dc.identifier.issn2193-4134
dc.identifier.scopus2-s2.0-85139608184en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s11694-022-01652-3#article-info
dc.identifier.urihttps://doi.prg/10.1007/s11694-022-01652-3
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3814
dc.identifier.wosWOS:000865673400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAkbulut, Zeynep
dc.institutionauthorAktaş, Ranan Gülhan
dc.institutionauthorDemirel, Gamze
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Food Measurement and Characterizationen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01900
dc.subjectPropolisen_US
dc.subjectAntioxidanten_US
dc.subjectLC–MS/MSen_US
dc.subjectAnticanceren_US
dc.subjectHepG2en_US
dc.titleLC–MS/MS analysis, antioxidant and anticancer efects of phenolic?rich extracts from Algerian propolis: a comparative studyen_US
dc.typeArticle
dspace.entity.typePublication

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