Evaluation of diagnostic components and management of childhood pulmonary tuberculosis: a prospective study from Istanbul, Turkey

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dc.authorid0000-0001-7785-7772en_US
dc.contributor.authorDemir, Ayşegül Doğan
dc.contributor.authorKut, Arif
dc.contributor.authorÖzaydın, Erhan
dc.contributor.authorNursoy, Mustafa
dc.contributor.authorÇakır, Fatma Betül
dc.contributor.authorKahraman, Feyza Ustabaş
dc.contributor.authorErenberk, Ufuk
dc.contributor.authorUzuner, Selçuk
dc.contributor.authorÇollak, Abdülhamit
dc.contributor.authorÇakın, Zeynep Ebru
dc.contributor.authorÇakır, Erkan
dc.date.accessioned2024-07-12T21:11:37Z
dc.date.available2024-07-12T21:11:37Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIntroduction: The diagnosis of childhood tuberculosis is difficult and most of the patients are diagnosed clinically. The objective of this study is to reveal the diagnostic and therapeutic components of childhood pulmonary tuberculosis and to analyze the changes that occurred in our country over the years. Methodology: All patients diagnosed with tuberculosis between 2006 and 2016 were included. Demographic characteristics, diagnostic and treatment outcomes were recorded and patients were followed up prospectively. Results: A total of 492 patients were included in the study. 97% had Bacillus Calmette-Guerin vaccine, 36% were diagnosed with microbiologically-confirmed tuberculosis and 64% were diagnosed with clinically-proven tuberculosis. 94% of the patients had symptoms consistent with tuberculosis, all patients had radiologic findings, 74% had a history of tuberculosis contact and 63% had tuberculin skin test positivity. The diagnoses included primary tuberculosis in 62%, secondary tuberculosis in 21%, progressive primary tuberculosis in 13% and miliary tuberculosis in 4%. 48% of the patients received a treatment regimen containing three drugs as the initial treatment, and drug-related side effects developed in 12%. Isoniazid resistance was detected in 13% of the patients and rifampicin resistance was detected in 8%. None of the patients died due to tuberculosis. In the last 50 years in Turkey, the rates of Bacillus Calmette-Guerin vaccination and diagnosis of tuberculosis cases have increased and the mortality rates have decreased over the years. Conclusions: Our study is one of the few prospective studies and revealed the differences between the recent data and the past 50 years in childhood tuberculosis in Turkey.en_US
dc.identifier.citationDemir, A.D., Kut, A. and at all. (2022). Evaluation of diagnostic components and management of childhood pulmonary tuberculosis: a prospective study from Istanbul, Turkey. The Journal of Infection in Developing Countries, 16(1), p.112-119.en_US
dc.identifier.doi10.3855/jidc.14505
dc.identifier.endpage119en_US
dc.identifier.issue1en_US
dc.identifier.pmid35192528en_US
dc.identifier.scopus2-s2.0-85125155232en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.prg/10.3855/jidc.14505
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4386
dc.identifier.volume16en_US
dc.identifier.wosWOS:000760556800015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKut, Arif
dc.language.isoenen_US
dc.publisherThe Journal of Infection in Developing Countriesen_US
dc.relation.ispartofThe Journal of Infection in Developing Countriesen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03548
dc.subjectTuberculosisen_US
dc.subjectChilden_US
dc.subjectDrug resistanceen_US
dc.titleEvaluation of diagnostic components and management of childhood pulmonary tuberculosis: a prospective study from Istanbul, Turkeyen_US
dc.typeArticle
dspace.entity.typePublication

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