The prognostic significance of histopathologic angioinvasion in stage I non-small cell lung cancer
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Society of Cardiovascular Surgery and Turkish Society of Thoracic Surgery
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Çalışmamızda akciğer kanserinde prognozu etkileyen histopatolojik bulgulardan vasküler invazyonun, lenfatik yayılım yapmamış erken evre akciğer kanserindeki prognostik önemi araştırıldı. Çalışma planı: Aralık 1997-Ocak 2004 yılları arasında küratif mediastinal lenf nodu rezeksiyonu uygulanmış erken evre (T1-2N0M0) küçük hücreli dışı akciğer kanserli 40 hasta (32 erkek, 8 kadın; ort. yaş 53.8±8.7 yıl; dağılım 35-69 yıl) geriye yönelik olarak değerlendirildi. Tümör histolojisi, grade, vasküler invazyon ve rezeksiyon büyüklüğü çalışılan kriterlerdendi. Patoloji kesitleri yeniden incelendi ve en az iki vasküler yapının invazyonu ve/veya damar lümeninde tumoral tromboz bulunması vasküler invazyon olarak tanımlandı. Bulgular: Üç yıllık hastalıksız sağkalım %67.2±7.5, beş yıllık sağkalım ise %64.5±7.6 olarak hesaplandı. Vasküler invazyonun olup olmamasına göre değerlendirme yapıldığında genel sağkalım süreleri arasında anlamlı farklılık saptanmadı (Log rank: 0.85; p:0.357; p>0.05). Bununla birlikte, adenokarsinomlu olguların lokal nüks veya uzak metastaz nedeni ile kötü prognoz gösterdiği tespit edildi (p<0.01). Sonuç: Olgu sayımız sınırlı olsa da, geriye yönelik çalışmamızda, erken evre akciğer kanserinde histolojik tipin, sağkalım açısından histolojik vasküler invazyondan daha etkin olduğu görüldü.
Background: We aimed to analyze the prognostic significance of vascular invasion, which is one of the histopathological features affecting the prognosis in early stage lung cancers. Methods: Forty early stage (T1-2N0M0) non-small cell lung cancer patients (32 males, 8 females; mean age 53.8±8.7 years; range 35 to 69 years) who underwent curative surgery with mediastinal lymph node dissection between December 1997 and January 2004 were retrospectively evaluated. Tumor histology, grade, vascular invasion, and the extent of resections were evaluated. Pathological slides were re-examined and invasion of at least two vascular structures and/or presence of tumoral thrombosis in the lumen of vessels were defined as vascular invasion. Results: Three-year disease free survival was found to be 67.2±7.5% and five-year survival was 64.5±7.6%. When an evaluation was done considering whether there was vascular invasion or not, there was not a significant difference (Log rank: 0.85; p:0.357; however, adenocarcinoma subtype was found to be related with unfavorable outcome with high local relapses and distant metastases (p<0.01). Conclusion: Despite the limited number of the cases in our retrospective study, it was found that in early stage lung cancer the type histology was far more prognostic than histological vascular invasion
Background: We aimed to analyze the prognostic significance of vascular invasion, which is one of the histopathological features affecting the prognosis in early stage lung cancers. Methods: Forty early stage (T1-2N0M0) non-small cell lung cancer patients (32 males, 8 females; mean age 53.8±8.7 years; range 35 to 69 years) who underwent curative surgery with mediastinal lymph node dissection between December 1997 and January 2004 were retrospectively evaluated. Tumor histology, grade, vascular invasion, and the extent of resections were evaluated. Pathological slides were re-examined and invasion of at least two vascular structures and/or presence of tumoral thrombosis in the lumen of vessels were defined as vascular invasion. Results: Three-year disease free survival was found to be 67.2±7.5% and five-year survival was 64.5±7.6%. When an evaluation was done considering whether there was vascular invasion or not, there was not a significant difference (Log rank: 0.85; p:0.357; however, adenocarcinoma subtype was found to be related with unfavorable outcome with high local relapses and distant metastases (p<0.01). Conclusion: Despite the limited number of the cases in our retrospective study, it was found that in early stage lung cancer the type histology was far more prognostic than histological vascular invasion
Açıklama
Anahtar Kelimeler
Erken evre akciğer kanseri, Histopatoloji, Vasküler invazyon, Early stage lung cancer, Histopathology, Vascular invasion
Kaynak
Türk Göğüs Kalp Damar Cerrahisi Derneği Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
17
Sayı
Künye
Tezel, Ç., Koşar, A., Ersev, A., Tezel, Y. ve Arman, B. (2009). The prognostic significance of histopathologic angioinvasion in stage I non-small cell cancer. 17, s. 267-271.
