The Effect of Captopril on Brain Apoptosis After Burn Injury in Rats
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TURKISH NEUROSURGICAL SOC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AIM:The purpose of this study was to determine the possible protective effects of captopril treatment against apoptosis in the brain induced by burn injury. MATERIAL and METHODS: Under ether anaesthesia, Wistar albino rats (200-250 g) were exposed to a 900C (burn) or 250C (sham) water bath for 10 s. The ACE group was treated with i.p. 10 mg/kg captopril immediately after burn injury and this treatment was repeated twice daily. At the end of the 24 hour, brain samples were taken. Apoptotic brain cells marked by terminal deoxynucleotidyl transferase-mediated d-UTP-nick end labeling (TUNEL) were evaluated in the cerebellum and midbrain of rats. RESULTS: Apoptotic cells in the cerebellum were significantly decreased after captopril treatment and found to be lower when compared to the burn group (p<0.001). In the midbrain of rats, the numbers of TUNEL-positive cells and apoptotic bodies were significantly increased in the burn group when compared to the control group (p<0.001).The burn-induced changes were reduced in the captopril-treated burn group (p<0.01). CONCLUSION: Captopril has beneficial effects in burn injury and should be assessed as a therapeutic agent in the management of this condition.
Açıklama
Anahtar Kelimeler
Captopril, Apoptosis, Burn injury, TUNEL
Kaynak
TURKISH NEUROSURGERY
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
23
Sayı
3
