Morphological and biomechanical effects of vitamin K2 on fracture healing: An animal study on the rat tibia fracture model

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dc.contributor.authorÜnal, Ömer Kays
dc.contributor.authorDağtaş, Mirza Zafer
dc.contributor.authorIpek, Belkiz Ongen
dc.contributor.authorSitar, Mustafa Erinc
dc.contributor.authorUgutmen, Ender
dc.date.accessioned2024-07-12T21:40:19Z
dc.date.available2024-07-12T21:40:19Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: The aim of this study was to evaluate the effects of vitamin K2 on fracture healing.Methods: Twenty-four 6-week-old male Wistar albino rats that had open tibia fractures induced were included in this study. They were divided into 2 groups of 12, a group that had vitamin K2 administered over 30 consecutive days and a control group. After 30 days, the rats were sacrificed, and from each group, 6 tibiae were selected for biomechanical testing to examine the mechanical strength of the callus tissue using the Instron 3-point bending test and 6 tibiae were selected for histological analysis to examine the density and organization of callus tissue using Allen's grading system and Huo et al's grading system. Furthermore, weekly x-rays were taken to evaluate bone union described by Lane and Sandhu, and osteocalcin, procollagen I N-terminal propeptide, and procollagen I C-terminal propeptide were examined in blood samples taken by intracardiac puncture during sacrification.Results: Breaking force (P = .047), breaking time (P = .019), stiffness (P = .039), fracture strength (P = .041), and Young's modulus (P = .032) showed a statistically significant increase in the K2 group. Procollagen I C-terminal propeptide (P = .024), procollagen I N-terminal propep -tide (.047), and osteocalcin (.048) levels were significantly higher in the K2 group compared to the control group. Furthermore, 3rd-week x-rays showed higher bone union scores according to the Lane and Sandhu method in the K2 group (P = .014). However, the histological grading systems of Allen and Huo et al did not show statistically significant differences between groups (P = .086, P = .07, respectively).Conclusion: In light of these findings, it could be concluded that vitamin K2 has a significant positive effect on fracture healing.en_US
dc.identifier.doi10.5152/j.aott.2023.21013
dc.identifier.endpage22en_US
dc.identifier.issn1017-995X
dc.identifier.issue1en_US
dc.identifier.pmid36939360en_US
dc.identifier.scopus2-s2.0-85150752108en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage17en_US
dc.identifier.trdizinid1177900en_US
dc.identifier.urihttps://doi.org/10.5152/j.aott.2023.21013
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177900
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7240
dc.identifier.volume57en_US
dc.identifier.wosWOS:000988342300003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Assoc Orthopaedics Traumatologyen_US
dc.relation.ispartofActa Orthopaedica Et Traumatologica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY05196
dc.subjectVitamin K2en_US
dc.subjectRat Fracture Modelen_US
dc.subjectFracture Unionen_US
dc.subjectMechanical Testingen_US
dc.subjectHistologic Analysisen_US
dc.titleMorphological and biomechanical effects of vitamin K2 on fracture healing: An animal study on the rat tibia fracture modelen_US
dc.typeArticle
dspace.entity.typePublication

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