Genetic markers indicate that 1,25-dihydroxyvitamin d treatment may not protect against hepatocellular carcinoma

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dc.authorid0000-0003-3771-3277en_US
dc.contributor.authorÖner, Çağrı
dc.contributor.authorÇolak, Ertuğrul
dc.date.accessioned2024-07-12T21:03:32Z
dc.date.available2024-07-12T21:03:32Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjectives: The impact of 1,25-dihydroxyvitamin D on hepatocellular carcinoma (HCC) cells is a complicated area. In this study, we aimed to clarify the effect of 1,25-dihydroxyvitamin D on HCC cells according to genetic markers. Methods: The optimal concentration of 1,25-dihydroxyvitamin D is treated to HepG2 cells (250 nM at the 48th hour). From treated HepG2 cells, total Ribonucleic Acid (RNA) was isolated, and Ki-67, MMP-2, MMP-9, HIF-1?, hTERT, and piR823 gene expressions were determined by SYBR Green-based real-time polymerase chain reaction. Results: : Increased expressions of Ki-67, hTERT, and piR-823 were determined compared with the control group at the 48th hour after treatment (p<0.001), while decreased gene expressions of MMP-2, MMP-9, and HIF-1? were observed compared with the control group (p<0.001). Conclusion: Currently, there are several different opinions about the usage of vitamin D, especially in HCC. In addition to researchers who argue that vitamin D has anticarcinogenic and protective properties, an increasing number of researchers argue that tumor cells can become aggressive after HCC occurs. According to our results, it was determined that vitamin D causes HepG2 HCC cells to become aggressive in terms of gene expression in the parameters used as a marker for proliferation, adhesion, and differentiation.en_US
dc.identifier.citationÖner, Ç. ve Çolak, E. (2021). Genetic markers indicate that 1,25-dihydroxyvitamin d treatment may not protect against hepatocellular carcinoma. Eurasian Journal of Medicine and Oncology, Kare Publishing. 5(2), s. 117-122.en_US
dc.identifier.doi10.14744/ejmo.2021.65874
dc.identifier.endpage122en_US
dc.identifier.issn2587-196X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85117246800en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage117en_US
dc.identifier.trdizinid488004en_US
dc.identifier.urihttps://www.ejmo.org/10.14744/ejmo.2021.65874/
dc.identifier.urihttps://doi.prg/10.14744/ejmo.2021.65874
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3678
dc.identifier.volume5en_US
dc.identifier.wosWOS:000672748800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÖner, Çağrı
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.ispartofEurasian Journal of Medicine and Oncologyen_US
dc.relation.publicationcategoryUlusal Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00828
dc.subject1.25-Dihydroxyvitamin Den_US
dc.subjecthepatocellular carcinomaen_US
dc.subjectmotilityen_US
dc.subjectPIWI interacting RNAen_US
dc.subjectproliferationen_US
dc.titleGenetic markers indicate that 1,25-dihydroxyvitamin d treatment may not protect against hepatocellular carcinomaen_US
dc.typeArticle
dspace.entity.typePublication

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